gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD33 on target cells, is internalized, and releases calicheamicin, which binds the DNA minor groove to cause double-strand breaks and apoptosis. Killing is determined by CD33 expression, not by DNA (minor groove) itself as a surface target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Calicheamicin payload binds DNA minor groove and induces double-strand breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05189639
disease_id_num_tar_ref
870
drug_id_num_tar_ref
2383