gene_symbol
ITGB3
hgnc_id
HGNC:6156
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ProAgio binds integrin αvβ3 on target cells and directly triggers caspase-dependent apoptosis, killing αvβ3-expressing stromal, endothelial, and tumor cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binding requires the αvβ3 heterodimer (ITGAV-ITGB3 complex)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06182072
disease_id_num_tar_ref
928
drug_id_num_tar_ref
2530