gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA vaccine is taken up by APCs, which present neoantigens and expand neoantigen-specific CD8+ T cells; these T cells recognize neoantigen–MHC on tumor cells and kill them via perforin/granzyme and Fas–FasL pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Personalized set of mutated peptide epitopes encoded by V940 (mRNA-4157), presented on HLA class I and II
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06623422
disease_id_num_tar_ref
109
drug_id_num_tar_ref
290