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Gene NCT ID Antigen/Ligand Binding Type Drug Name Drug Type Drug NCI Concept Drug Category Drug Class Drug Description Drug Mechanism of Action Cytotoxicity Cytotoxicity Type Target Cytotoxicity Mechanism Disease Disease Type Tissue OncoTree Main Type OncoTree Name Annotation Status
CD3E NCT06571825 CD3 epsilon (TCR-CD3 complex) antigen recognition Antithymocyte globulin RELEVANT_DRUG INHIBITORY ANTIBODY Inhibitor Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis. Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis. YES DIRECT Polyclonal anti–T-cell IgG binds CD3ε on T cells and triggers complement-dependent lysis, Fc-mediated ADCC, and apoptosis, depleting CD3+ T cells. Acute Myeloid Leukemia CANCER Myeloid Acute Myeloid Leukemia Acute Myeloid Leukemia ai
CD4 NCT06571825 CD4 antigen recognition Antithymocyte globulin RELEVANT_DRUG INHIBITORY ANTIBODY Inhibitor Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis. Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis. YES DIRECT ATG antibodies bind CD4 on T cells and trigger complement-dependent lysis, Fc-mediated ADCC by effector cells, and apoptosis, depleting CD4+ cells. Acute Myeloid Leukemia CANCER Myeloid Acute Myeloid Leukemia Acute Myeloid Leukemia ai
CD8A NCT06571825 CD8 alpha antigen recognition Antithymocyte globulin RELEVANT_DRUG INHIBITORY ANTIBODY Inhibitor Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis. Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis. YES DIRECT Polyclonal anti–T-cell IgG binds CD8 on T cells and induces complement-dependent lysis, Fc-mediated ADCC, and apoptosis, directly depleting CD8+ cells. Acute Myeloid Leukemia CANCER Myeloid Acute Myeloid Leukemia Acute Myeloid Leukemia ai
ITGAL NCT06571825 CD11a (LFA-1 alpha) antigen recognition Antithymocyte globulin RELEVANT_DRUG INHIBITORY ANTIBODY Inhibitor Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis. Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis. YES DIRECT Polyclonal IgG in ATG binds CD11a (among other T‑cell antigens) and depletes target cells via complement-dependent cytotoxicity, Fc-mediated ADCC, and apoptosis induction. Acute Myeloid Leukemia CANCER Myeloid Acute Myeloid Leukemia Acute Myeloid Leukemia ai
ITGB2 NCT06571825 CD18 (LFA-1 beta) antigen recognition Antithymocyte globulin RELEVANT_DRUG INHIBITORY ANTIBODY Inhibitor Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis. Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis. YES DIRECT Antithymocyte globulin contains antibodies that bind CD18 on T cells, triggering complement-dependent cytotoxicity and Fc-mediated ADCC, and can induce apoptosis, directly depleting the bound cells. Acute Myeloid Leukemia CANCER Myeloid Acute Myeloid Leukemia Acute Myeloid Leukemia ai
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