Anti-CD38 monoclonal antibody that depletes CD38-positive clonal plasma cells via ADCC, CDC, apoptosis, and immune modulation.
Human IgG1κ anti-CD38 monoclonal antibody that binds CD38 on clonal plasma cells, triggering Fc-mediated ADCC, ADCP, complement-dependent cytotoxicity, and direct apoptosis; also depletes CD38+ immunosuppressive cells (Tregs, B cells, MDSCs), enhancing antitumor immunity.
YES
DIRECT
Anti-CD38 IgG1 mAb binds CD38 on target cells and triggers Fc-mediated ADCC (NK cells), ADCP (macrophages), complement-dependent cytotoxicity (CDC), and can induce direct apoptosis upon binding/crosslinking.
Anti-CD38 IgG1 monoclonal antibody mediating ADCC, CDC, and ADCP against CD38+ myeloma cells.
Human IgG1κ monoclonal antibody targeting CD38 on myeloma and other hematologic tumor cells; binding triggers immune effector–mediated killing (ADCC, CDC, ADCP) and can directly induce apoptosis, while depleting CD38+ immunosuppressive cells (Tregs, Bregs, MDSCs) to enhance antitumor immunity.
YES
DIRECT
Daratumumab binds CD38 on target cells and, via its Fc region, recruits immune effectors to kill by ADCC (NK cells), CDC (complement), and ADCP (macrophages); crosslinking can also directly induce apoptosis.
CD20×CD3 bispecific T‑cell–engaging antibody that redirects cytotoxic T cells to kill CD20+ B cells.
CD20xCD3 bispecific antibody that binds CD3 on T cells and CD20 on B cells, crosslinks them to form an immune synapse, activating and redirecting cytotoxic T cells to kill CD20-positive B-cell malignancies.
YES
DIRECT
Bispecific antibody links CD3+ T cells to CD20+ cells, forming an immune synapse and activating T cells to kill via perforin/granzyme-mediated cytolysis and apoptosis.
CD20×CD3 bispecific T‑cell–engaging antibody that redirects cytotoxic T cells to kill CD20+ B cells.
CD20xCD3 bispecific antibody that binds CD3 on T cells and CD20 on B cells, crosslinks them to form an immune synapse, activating and redirecting cytotoxic T cells to kill CD20-positive B-cell malignancies.
NO
INDIRECT
Epcoritamab engages CD3ε on T cells and CD20 on B cells to form an immune synapse, activating T cells to kill CD20+ B cells via perforin/granzyme cytolysis; CD3ε+ T cells are not killed.
Anti-CD20 monoclonal antibody causing B‑cell depletion via ADCC, CDC, and direct cell death.
Chimeric anti-CD20 monoclonal antibody that binds CD20 on B cells and depletes them via antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and direct induction of cell death.
YES
DIRECT
Rituximab binds CD20 on B cells and kills them via Fc-mediated ADCC by immune effector cells, complement-dependent cytotoxicity, and direct induction of apoptosis.