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Gene NCT ID Antigen/Ligand Binding Type Drug Name Drug Type Drug NCI Concept Drug Category Drug Class Drug Description Drug Mechanism of Action Cytotoxicity Cytotoxicity Type Target Cytotoxicity Mechanism Disease Disease Type Tissue OncoTree Main Type OncoTree Name Annotation Status
CD3E NCT06075706 CD3 epsilon antigen recognition Anti-thymocyte globulin RELEVANT_DRUG CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. YES DIRECT Anti-thymocyte globulin binds CD3ε on T cells and induces complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting the target cells. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
CD3D NCT06075706 CD3 delta antigen recognition Anti-thymocyte globulin RELEVANT_DRUG CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. YES DIRECT Anti-thymocyte globulin binds CD3 (including the CD3 delta chain) on T cells and triggers complement-dependent lysis and Fc-mediated ADCC/phagocytosis, directly depleting the targeted T cells. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
CD3G NCT06075706 CD3 gamma antigen recognition Anti-thymocyte globulin RELEVANT_DRUG CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. YES DIRECT ATG antibodies bind the CD3 complex (including CD3γ) on T cells, triggering complement-dependent lysis and Fc-mediated effector killing (ADCC/phagocytosis), leading to direct depletion of the target-expressing cells. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
CD247 NCT06075706 CD3 zeta (CD247) antigen recognition Anti-thymocyte globulin RELEVANT_DRUG CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. YES DIRECT Anti-thymocyte globulin binds CD3 on T cells (including the CD3 complex containing CD247) and depletes them via complement-dependent lysis and Fc-mediated ADCC/phagocytosis. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
CD4 NCT06075706 CD4 antigen recognition Anti-thymocyte globulin RELEVANT_DRUG CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. YES DIRECT Anti-thymocyte globulin binds CD4 on T cells and induces complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting CD4+ cells. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
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