Polyclonal antibody preparation that depletes T cells and provides immunosuppression.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression.
YES
DIRECT
Antibodies in anti-thymocyte globulin bind CD8α on T cells and induce complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting CD8+ cells.
Polyclonal antibody preparation that depletes T cells and provides immunosuppression.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression.
YES
DIRECT
Polyclonal antibodies in ATG bind CD25 on T cells and trigger complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting CD25+ cells.
An antibody–drug conjugate consisting of a humanized anti–Trop-2 IgG1 monoclonal antibody linked to the topoisomerase I inhibitor SN-38; delivers SN-38 to Trop-2–expressing tumor cells to induce DNA damage and apoptosis and may enhance radiosensitivity.
Humanized anti–Trop-2 IgG1 antibody–drug conjugate linked to SN-38. After binding Trop-2 on tumor cells and internalization, SN-38 is released to inhibit topoisomerase I, stabilizing Topo I–DNA complexes, causing DNA breaks, blocking replication, and inducing apoptosis; may enhance radiosensitivity.
NO
INDIRECT
The ADC binds Trop-2 on tumor cells, is internalized, and releases SN-38, which inhibits topoisomerase I to cause DNA damage and apoptosis; topoisomerase I is not the cell-selective binding target.
Polyclonal antibody preparation that depletes T cells and provides immunosuppression.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression.
YES
DIRECT
Anti-thymocyte globulin binds CD28 on T cells and triggers complement-dependent lysis and Fc receptor–mediated ADCC/phagocytosis, depleting the bound cells.
Polyclonal antibody preparation that depletes T cells and provides immunosuppression.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression.
YES
DIRECT
Anti-thymocyte globulin contains antibodies that bind T-cell surface antigens including CD45; bound cells are eliminated via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis).