gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody targets SLAMF7 on tumor cells; its Fc engages CD16A on NK cells to activate ADCC (and possibly CDC/phagocytosis) against SLAMF7+ targets. CD16A-expressing cells are effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement on NK cells to drive ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06205823
disease_id_num_tar_ref
2105
drug_id_num_tar_ref
5625