gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The bispecific binds CD3 on T cells to activate them; the activated T cells then kill BCMA-expressing tumor cells via immune synapse formation and perforin/granzyme-mediated lysis, not CD3+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3-binding arm typically recognizes the epsilon chain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06205823
disease_id_num_tar_ref
2105
drug_id_num_tar_ref
5626