gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The bispecific binds CD3 on T cells to activate them and bridge to GPRC5D+ tumor cells; activated T cells kill the GPRC5D-expressing tumor via perforin/granzyme. CD3+ T cells are not the cytotoxic targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor CD3 complex subunit targeted for T-cell engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06205823
disease_id_num_tar_ref
2105
drug_id_num_tar_ref
5627