gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds BCMA, is internalized, linker is cleaved to release a cytotoxic payload that disrupts microtubules or damages DNA, inducing apoptosis; Fc-mediated ADCC/CDC may contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Internalizing cell-surface receptor; ADC payload varies by product
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06205823
disease_id_num_tar_ref
2105
drug_id_num_tar_ref
5630