gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Muromonab-CD3 binds CD3ε on T cells, causing TCR cross-linking and activation-induced apoptosis, and its Fc mediates ADCC/CDC, depleting CD3+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular epitope on CD3 epsilon within the TCR-CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06684899
disease_id_num_tar_ref
2180
drug_id_num_tar_ref
5823