gene_symbol
HLA-E
hgnc_id
HGNC:4962
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD94-based CAR-T cells recognize HLA-E on target cells, triggering immune-synapse formation and T-cell effector killing via perforin/granzyme release and death-receptor pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Non-classical MHC class I; recognition of HLA-E/peptide complex via CD94-based domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05893693
disease_id_num_tar_ref
2535
drug_id_num_tar_ref
6769