Rabbit polyclonal antilymphocyte globulin used for in vivo T-cell depletion to reduce graft-versus-host disease risk.
Rabbit polyclonal IgG against multiple human T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA) that depletes T lymphocytes via complement-dependent cytotoxicity, Fc-mediated ADCC/phagocytosis, and apoptosis, producing in vivo T‑cell immunosuppression to reduce GVHD risk.
YES
DIRECT
Polyclonal IgG in rATG binds CD45 on T cells and triggers complement-dependent cytotoxicity and Fc-mediated ADCC/phagocytosis, also inducing apoptosis, leading to direct depletion of CD45+ T cells.
Polyclonal antibody that depletes T cells to reduce rejection and GVHD.
Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD.
YES
DIRECT
Anti-thymocyte globulin contains antibodies that bind CD29 on T cells, triggering complement-dependent cytotoxicity and Fc-mediated ADCC/phagocytosis to deplete those cells.
Polyclonal antibody that depletes T cells to reduce rejection and GVHD.
Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD.
NO
INDIRECT
Anti-thymocyte globulin depletes T cells by binding multiple other T-cell antigens and inducing complement-mediated lysis and Fc-dependent ADCC/phagocytosis; CD44 is not a direct binding target in this mechanism.
Polyclonal antibody that depletes T cells to reduce rejection and GVHD.
Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD.
NO
INDIRECT
Anti-thymocyte globulin depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis against multiple T‑cell antigens; CD49d is not a defined target, so CD49d+ cells are not directly killed via this antigen.
Polyclonal antibody that depletes T cells to reduce rejection and GVHD.
Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD.
NO
INDIRECT
Anti-thymocyte globulin depletes T cells by binding multiple T-cell antigens (via complement lysis and Fc-mediated ADCC/phagocytosis); Fas/CD95 is not a defined binding target, so Fas-expressing cells are not specifically targeted.