Polyclonal antibody that depletes T cells to reduce rejection and GVHD.
Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD.
YES
DIRECT
ATG binds CD45 on T cells and triggers complement-dependent cytotoxicity and Fc-mediated ADCC/phagocytosis, leading to lysis and depletion of the target cells.
Polyclonal antibody that depletes T cells to reduce rejection and GVHD.
Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD.
YES
DIRECT
Anti-thymocyte globulin contains antibodies that bind CD11a (LFA-1 alpha) on T cells and deplete them via complement-dependent lysis and Fc-mediated ADCC/phagocytosis.
Polyclonal antibody that depletes T cells to reduce rejection and GVHD.
Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD.
YES
DIRECT
Polyclonal antibodies bind CD18 (among other T‑cell antigens) and trigger complement-dependent lysis and Fc receptor–mediated ADCC/phagocytosis, directly depleting CD18+ T cells.
Polyclonal antibody that depletes T cells to reduce rejection and GVHD.
Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD.
NO
INDIRECT
Not targeted. Anti-thymocyte globulin binds T‑cell antigens (e.g., CD2/CD3/CD45) and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis; it does not directly target HLA-DR alpha–expressing cells.
Polyclonal antibody that depletes T cells to reduce rejection and GVHD.
Polyclonal anti–T-cell IgG that binds multiple T-cell surface antigens and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis, producing immunosuppression to reduce rejection and GVHD.
YES
DIRECT
Polyclonal anti–T‑cell IgG binds T‑cell antigens (including CD52) and depletes those cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis.