Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
YES
DIRECT
rATG contains antibodies that bind CD4 on T cells and deplete them via complement-dependent cytotoxicity and Fc-mediated ADCC/phagocytosis, inducing apoptosis and lysis of CD4+ cells.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
YES
DIRECT
rATG contains antibodies that bind T‑cell antigens including CD8; bound cells are eliminated via complement-dependent cytotoxicity and Fc-mediated ADCC, with induction of apoptosis, depleting CD8+ T cells.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
YES
DIRECT
rATG binds CD5 on lymphocytes and triggers complement-dependent lysis and Fc receptor–mediated ADCC/apoptosis, leading to depletion of CD5+ cells.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
YES
DIRECT
rATG antibodies bind CD6 on T cells and mediate complement-dependent lysis and Fc-dependent ADCC, with additional apoptosis, leading to depletion of CD6+ lymphocytes.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
YES
DIRECT
Polyclonal anti-thymocyte IgG binds CD7 on T cells and induces complement-mediated lysis, Fc-mediated ADCC, and apoptosis, depleting CD7+ cells.