Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
YES
DIRECT
Polyclonal IgG binds CD18 on leukocytes/T cells and induces complement-dependent lysis and Fc-mediated ADCC, with additional apoptosis, depleting the target-expressing cells.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
YES
DIRECT
rATG contains antibodies that bind ICAM1 on cells, leading to complement-dependent lysis and Fc-mediated ADCC, and can also induce apoptosis of the bound ICAM1+ cells.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
YES
DIRECT
rATG antibodies bind CD95 (and other T‑cell antigens), leading to complement-dependent lysis and Fc-mediated ADCC; Fas cross-linking can also trigger apoptosis.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
YES
DIRECT
Polyclonal rATG antibodies can bind HLA‑DR on leukocytes and trigger complement-dependent cytotoxicity and Fc-mediated ADCC/apoptosis, depleting HLA‑DR–expressing cells.
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
YES
DIRECT
rATG contains polyclonal antibodies that can bind HLA class I (e.g., HLA-A) on lymphocytes; bound cells are eliminated via complement-dependent cytotoxicity and Fc-mediated ADCC, with apoptosis contributing to depletion.