Polyclonal antilymphocyte/antithymocyte globulin that depletes T cells.
Polyclonal anti–T-lymphocyte immunoglobulin that binds multiple T‑cell surface antigens and induces complement-dependent cytotoxicity and Fc-mediated clearance (ADCC/phagocytosis), leading to rapid T‑cell depletion and immunosuppression.
YES
DIRECT
ATG binds CD18 (LFA-1) on T cells and induces complement-dependent lysis and Fc-mediated effector killing (ADCC/phagocytosis), depleting the bound cells.
Polyclonal antilymphocyte/antithymocyte globulin that depletes T cells.
Polyclonal anti–T-lymphocyte immunoglobulin that binds multiple T‑cell surface antigens and induces complement-dependent cytotoxicity and Fc-mediated clearance (ADCC/phagocytosis), leading to rapid T‑cell depletion and immunosuppression.
YES
DIRECT
ATG antibodies bind CD28 on T cells and induce complement-dependent lysis and Fc receptor–mediated ADCC/phagocytosis, directly depleting CD28+ cells.
Polyclonal antilymphocyte/antithymocyte globulin that depletes T cells.
Polyclonal anti–T-lymphocyte immunoglobulin that binds multiple T‑cell surface antigens and induces complement-dependent cytotoxicity and Fc-mediated clearance (ADCC/phagocytosis), leading to rapid T‑cell depletion and immunosuppression.
YES
DIRECT
ATG antibodies bind CD45 on T cells, activating complement-mediated lysis and Fc-dependent ADCC/phagocytosis, causing rapid T-cell depletion.
Polyclonal antilymphocyte/antithymocyte globulin that depletes T cells.
Polyclonal anti–T-lymphocyte immunoglobulin that binds multiple T‑cell surface antigens and induces complement-dependent cytotoxicity and Fc-mediated clearance (ADCC/phagocytosis), leading to rapid T‑cell depletion and immunosuppression.
YES
DIRECT
ATG contains antibodies that bind HLA-DR on the cell surface and induce complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting HLA-DR–positive cells.
Polyclonal antilymphocyte/antithymocyte globulin that depletes T cells.
Polyclonal anti–T-lymphocyte immunoglobulin that binds multiple T‑cell surface antigens and induces complement-dependent cytotoxicity and Fc-mediated clearance (ADCC/phagocytosis), leading to rapid T‑cell depletion and immunosuppression.
NO
INDIRECT
ATG binds multiple T‑cell surface antigens and depletes T cells via complement-mediated lysis and Fc-dependent ADCC/phagocytosis; it does not specifically target HLA-A, so HLA-A–expressing cells are not directly killed.