Off-the-shelf, allogeneic, lentiviral-engineered double-negative T cells (DNTs) expressing an anti-CD19 chimeric antigen receptor (CAR) to target and kill CD19-positive malignant B cells.
Off-the-shelf allogeneic double-negative T cells engineered with an anti-CD19 chimeric antigen receptor bind CD19 on malignant B cells; CAR signaling activates the DNTs to exert cytotoxicity and eliminate CD19-positive tumor cells.
Anti-CD19 CAR-expressing double-negative T cells bind CD19+ cells and, upon CAR signaling, kill them via T-cell cytotoxic pathways (perforin/granzyme and Fas–FasL-mediated apoptosis).
Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis.
Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis.
Antithymocyte globulin binds CD2 on T cells and induces complement-dependent cytotoxicity and Fc-mediated ADCC, and can trigger apoptosis, leading to depletion of CD2+ cells.
Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis.
Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis.
Polyclonal anti–T-cell IgG binds CD3ε on T cells and triggers complement-dependent lysis, Fc-mediated ADCC, and apoptosis, depleting CD3+ T cells.
Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis.
Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis.
ATG antibodies bind CD4 on T cells and trigger complement-dependent lysis, Fc-mediated ADCC by effector cells, and apoptosis, depleting CD4+ cells.
Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis.
Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis.
Polyclonal anti–T-cell IgG binds CD8 on T cells and induces complement-dependent lysis, Fc-mediated ADCC, and apoptosis, directly depleting CD8+ cells.