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antigen recognition (3404)

other (145)

receptor ligand recognition (192)

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ai (3167)

manual_review_required (574)

Disease Type

CANCER (2959)

NON-CANCER (780)

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Gene	NCT ID	Antigen/Ligand	Binding Type	Drug Name	Drug Category	Drug Class	Drug Description	Drug Mechanism of Action	Target Cytotoxicity Mechanism	Disease	Disease Type	Tissue	OncoTree Main Type	OncoTree Name	Annotation Status
ITGAL	NCT06571825	CD11a (LFA-1 alpha)	antigen recognition	Antithymocyte globulin	INHIBITORY ANTIBODY	Inhibitor	Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis.	Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis.	Polyclonal IgG in ATG binds CD11a (among other T‑cell antigens) and depletes target cells via complement-dependent cytotoxicity, Fc-mediated ADCC, and apoptosis induction.	Acute Myeloid Leukemia	CANCER	Myeloid	Acute Myeloid Leukemia	Acute Myeloid Leukemia	ai
ITGB2	NCT06571825	CD18 (LFA-1 beta)	antigen recognition	Antithymocyte globulin	INHIBITORY ANTIBODY	Inhibitor	Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis.	Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis.	Antithymocyte globulin contains antibodies that bind CD18 on T cells, triggering complement-dependent cytotoxicity and Fc-mediated ADCC, and can induce apoptosis, directly depleting the bound cells.	Acute Myeloid Leukemia	CANCER	Myeloid	Acute Myeloid Leukemia	Acute Myeloid Leukemia	ai
IL2RA	NCT06571825	CD25 (IL-2 receptor alpha)	antigen recognition	Antithymocyte globulin	INHIBITORY ANTIBODY	Inhibitor	Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis.	Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis.	ATG contains antibodies that bind CD25 on T cells, leading to complement-dependent lysis, Fc-mediated ADCC, and apoptosis of CD25+ cells.	Acute Myeloid Leukemia	CANCER	Myeloid	Acute Myeloid Leukemia	Acute Myeloid Leukemia	ai
CD28	NCT06571825	CD28	antigen recognition	Antithymocyte globulin	INHIBITORY ANTIBODY	Inhibitor	Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis.	Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis.	Polyclonal anti–T-cell IgG binds CD28 on T cells and induces complement-dependent cytotoxicity, Fc-mediated ADCC, and apoptosis, depleting CD28+ cells.	Acute Myeloid Leukemia	CANCER	Myeloid	Acute Myeloid Leukemia	Acute Myeloid Leukemia	ai
PTPRC	NCT06571825	CD45 (leukocyte common antigen)	antigen recognition	Antithymocyte globulin	INHIBITORY ANTIBODY	Inhibitor	Polyclonal antibody preparation that depletes T cells for GVHD prophylaxis.	Polyclonal IgG directed against multiple T-cell antigens that binds and depletes T cells via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, leading to immunosuppression and GVHD prophylaxis.	Polyclonal antibodies bind CD45 on T cells and deplete them via complement-dependent cytotoxicity and Fc-mediated ADCC, with additional induction of apoptosis.	Acute Myeloid Leukemia	CANCER	Myeloid	Acute Myeloid Leukemia	Acute Myeloid Leukemia	ai