Polyclonal anti-T-cell antibody used for T-cell depletion to reduce rejection and GVHD.
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-dependent cytotoxicity and Fc-mediated effector functions (e.g., ADCC and phagocytosis), resulting in profound T-cell immunosuppression to reduce rejection and GVHD.
YES
DIRECT
ATG contains antibodies that bind CD2 on T cells/NK cells, triggering complement-dependent lysis and Fc-mediated effector functions (ADCC and phagocytosis) to deplete the cells.
Polyclonal anti-T-cell antibody used for T-cell depletion to reduce rejection and GVHD.
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-dependent cytotoxicity and Fc-mediated effector functions (e.g., ADCC and phagocytosis), resulting in profound T-cell immunosuppression to reduce rejection and GVHD.
YES
DIRECT
ATG binds CD4 on T cells and induces complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting CD4+ cells.
Polyclonal anti-T-cell antibody used for T-cell depletion to reduce rejection and GVHD.
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-dependent cytotoxicity and Fc-mediated effector functions (e.g., ADCC and phagocytosis), resulting in profound T-cell immunosuppression to reduce rejection and GVHD.
YES
DIRECT
ATG antibodies bind CD8α on T cells and induce complement-dependent lysis and Fc-mediated effector killing (ADCC and phagocytosis), depleting CD8+ cells.
Polyclonal anti-T-cell antibody used for T-cell depletion to reduce rejection and GVHD.
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-dependent cytotoxicity and Fc-mediated effector functions (e.g., ADCC and phagocytosis), resulting in profound T-cell immunosuppression to reduce rejection and GVHD.
YES
DIRECT
ATG antibodies bind CD25 on T cells, triggering complement-dependent lysis and Fc-mediated effector functions (ADCC and phagocytosis) that deplete the target cells.
Polyclonal anti-T-cell antibody used for T-cell depletion to reduce rejection and GVHD.
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-dependent cytotoxicity and Fc-mediated effector functions (e.g., ADCC and phagocytosis), resulting in profound T-cell immunosuppression to reduce rejection and GVHD.
YES
DIRECT
ATG binds CD28 on T cells (among other T‑cell antigens), leading to complement-dependent lysis and Fc-mediated ADCC/phagocytosis that depletes CD28+ T cells.