A polyclonal immunoglobulin preparation that depletes T cells via complement-mediated lysis and apoptosis and exerts immune-modulatory effects; used peri-transplant to prevent graft-versus-host disease.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-mediated lysis, apoptosis, and Fc-dependent cytotoxicity, with additional immunomodulatory effects; used peri-transplant to suppress alloreactive T cells and prevent GVHD.
YES
DIRECT
ATG antibodies bind CD4 on T cells and trigger complement-dependent lysis and Fc-mediated ADCC, and can induce apoptosis of the bound cells.
A polyclonal immunoglobulin preparation that depletes T cells via complement-mediated lysis and apoptosis and exerts immune-modulatory effects; used peri-transplant to prevent graft-versus-host disease.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-mediated lysis, apoptosis, and Fc-dependent cytotoxicity, with additional immunomodulatory effects; used peri-transplant to suppress alloreactive T cells and prevent GVHD.
YES
DIRECT
ATG antibodies bind CD8 on T cells, triggering complement-dependent lysis and Fc-mediated effector killing (ADCC/phagocytosis), and can also induce apoptosis.
A polyclonal immunoglobulin preparation that depletes T cells via complement-mediated lysis and apoptosis and exerts immune-modulatory effects; used peri-transplant to prevent graft-versus-host disease.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-mediated lysis, apoptosis, and Fc-dependent cytotoxicity, with additional immunomodulatory effects; used peri-transplant to suppress alloreactive T cells and prevent GVHD.
YES
DIRECT
Polyclonal ATG antibodies bind CD11a (LFA-1 alpha) on T cells, triggering complement-dependent lysis and Fc-mediated ADCC/apoptosis, depleting the target-expressing cells.
A polyclonal immunoglobulin preparation that depletes T cells via complement-mediated lysis and apoptosis and exerts immune-modulatory effects; used peri-transplant to prevent graft-versus-host disease.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-mediated lysis, apoptosis, and Fc-dependent cytotoxicity, with additional immunomodulatory effects; used peri-transplant to suppress alloreactive T cells and prevent GVHD.
YES
DIRECT
ATG contains polyclonal antibodies that bind T‑cell surface antigens including LFA‑1 (CD18), leading to complement-dependent lysis and Fc‑mediated ADCC/apoptosis of the bound cells.
A polyclonal immunoglobulin preparation that depletes T cells via complement-mediated lysis and apoptosis and exerts immune-modulatory effects; used peri-transplant to prevent graft-versus-host disease.
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-mediated lysis, apoptosis, and Fc-dependent cytotoxicity, with additional immunomodulatory effects; used peri-transplant to suppress alloreactive T cells and prevent GVHD.
YES
DIRECT
ATG contains antibodies that bind CD25 on activated T cells, leading to complement-dependent lysis and Fc-mediated cytotoxicity/phagocytosis (ADCC), and can also trigger apoptosis of the bound cells.