Monobactam antibiotic that inhibits gram-negative bacterial cell-wall synthesis by binding penicillin-binding proteins.
Monobactam beta-lactam antibiotic that binds and inhibits penicillin-binding protein 3 (PBP-3) in gram-negative bacteria, blocking cell-wall peptidoglycan synthesis and leading to loss of wall integrity, lysis, and bacterial death; resistant to many beta-lactamases.
YES
DIRECT
Aztreonam binds PBP3 (FtsI) in Gram-negative bacteria, inhibiting peptidoglycan crosslinking and cell-wall synthesis, leading to loss of wall integrity and osmotic lysis (bactericidal).
Allogeneic gamma-delta T cells engineered by mRNA electroporation to transiently express an NKG2D-based CAR that binds NKG2D ligands (MICA/MICB, ULBP1-6) on stressed tumor and tumor microenvironment cells; engagement activates CAR and native gamma-delta TCR/DNAM-1 signaling to drive pro-inflammatory cytokine release and MHC-independent cytotoxic killing.
YES
DIRECT
Engineered gamma-delta T cells expressing an NKG2D-based CAR bind MICA on target cells, activating MHC-independent cytotoxicity via perforin/granzyme-mediated lysis.
Allogeneic gamma-delta T cells engineered by mRNA electroporation to transiently express an NKG2D-based CAR that binds NKG2D ligands (MICA/MICB, ULBP1-6) on stressed tumor and tumor microenvironment cells; engagement activates CAR and native gamma-delta TCR/DNAM-1 signaling to drive pro-inflammatory cytokine release and MHC-independent cytotoxic killing.
YES
DIRECT
NKG2D-based CAR γδ T cells bind MICB on target cells, activating CAR and native γδ TCR/DNAM-1 signaling to induce MHC-independent cytolysis via perforin/granzyme release and pro-inflammatory cytokines.
Allogeneic gamma-delta T cells engineered by mRNA electroporation to transiently express an NKG2D-based CAR that binds NKG2D ligands (MICA/MICB, ULBP1-6) on stressed tumor and tumor microenvironment cells; engagement activates CAR and native gamma-delta TCR/DNAM-1 signaling to drive pro-inflammatory cytokine release and MHC-independent cytotoxic killing.
YES
DIRECT
NKG2D-based CAR on allogeneic gamma-delta T cells binds ULBP1 on target cells, triggering CAR/TCR signaling and degranulation (perforin/granzyme) to kill the bound cells in an MHC-independent manner.
Allogeneic gamma-delta T cells engineered by mRNA electroporation to transiently express an NKG2D-based CAR that binds NKG2D ligands (MICA/MICB, ULBP1-6) on stressed tumor and tumor microenvironment cells; engagement activates CAR and native gamma-delta TCR/DNAM-1 signaling to drive pro-inflammatory cytokine release and MHC-independent cytotoxic killing.
YES
DIRECT
NKG2D-CAR–engineered gamma-delta T cells bind ULBP2 on target cells, triggering T-cell activation and MHC-independent cytolysis via perforin/granzyme release (and related cytotoxic pathways).