Polyclonal anti-T-cell antibody used in conditioning for T-cell depletion prior to HSCT.
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA-DR), depleting T lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, resulting in profound T-cell immunosuppression and reduction of alloreactivity before HSCT.
YES
DIRECT
ATG binds CD3 (including the CD3δ chain) on T cells and induces killing via complement-dependent cytotoxicity and Fc-mediated ADCC, and can also trigger apoptosis of the bound T cells.
Polyclonal anti-T-cell antibody used in conditioning for T-cell depletion prior to HSCT.
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA-DR), depleting T lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, resulting in profound T-cell immunosuppression and reduction of alloreactivity before HSCT.
YES
DIRECT
ATG binds CD3 (including the CD3γ chain) on T cells and depletes them via complement-dependent cytotoxicity and Fc receptor–mediated ADCC; it can also induce apoptosis.
Polyclonal anti-T-cell antibody used in conditioning for T-cell depletion prior to HSCT.
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA-DR), depleting T lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, resulting in profound T-cell immunosuppression and reduction of alloreactivity before HSCT.
YES
DIRECT
ATG binds CD3 zeta on T cells; the antibody Fc activates complement and recruits Fc receptor–bearing effectors to mediate CDC and ADCC, and can trigger apoptosis, depleting the target cells.
Polyclonal anti-T-cell antibody used in conditioning for T-cell depletion prior to HSCT.
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA-DR), depleting T lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, resulting in profound T-cell immunosuppression and reduction of alloreactivity before HSCT.
YES
DIRECT
ATG binds CD4 on T cells; bound antibody triggers complement-dependent cytotoxicity, Fc-mediated ADCC by effector cells, and induces apoptosis, leading to depletion of CD4+ T cells.
Polyclonal anti-T-cell antibody used in conditioning for T-cell depletion prior to HSCT.
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA-DR), depleting T lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, resulting in profound T-cell immunosuppression and reduction of alloreactivity before HSCT.
YES
DIRECT
ATG binds CD8α on T cells; Fc engagement triggers complement-dependent cytotoxicity and ADCC, and can induce apoptosis, depleting CD8+ cells.