Rabbit polyclonal anti-T-cell globulin used for in vivo T-cell depletion and immunosuppression.
Rabbit polyclonal anti‑thymocyte globulin that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, adhesion/HLA molecules) and depletes T lymphocytes via complement‑dependent cytotoxicity, antibody‑dependent cellular cytotoxicity, and apoptosis, resulting in potent in vivo T‑cell immunosuppression.
YES
DIRECT
Polyclonal anti-thymocyte antibodies bind CD8 (including the beta chain) on T cells, triggering complement-dependent cytotoxicity and Fc-mediated ADCC, and can also induce apoptosis, depleting CD8+ cells.
Rabbit polyclonal anti-T-cell globulin used for in vivo T-cell depletion and immunosuppression.
Rabbit polyclonal anti‑thymocyte globulin that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, adhesion/HLA molecules) and depletes T lymphocytes via complement‑dependent cytotoxicity, antibody‑dependent cellular cytotoxicity, and apoptosis, resulting in potent in vivo T‑cell immunosuppression.
YES
DIRECT
Rabbit anti-thymocyte globulin contains antibodies that bind adhesion molecules such as CD11a on T cells, triggering complement-dependent lysis, Fc-mediated ADCC, and apoptosis to deplete the cells.
Rabbit polyclonal anti-T-cell globulin used for in vivo T-cell depletion and immunosuppression.
Rabbit polyclonal anti‑thymocyte globulin that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, adhesion/HLA molecules) and depletes T lymphocytes via complement‑dependent cytotoxicity, antibody‑dependent cellular cytotoxicity, and apoptosis, resulting in potent in vivo T‑cell immunosuppression.
YES
DIRECT
Thymoglobulin includes antibodies to adhesion molecules such as CD18; antibody binding to CD18+ cells activates complement and engages Fc receptor–bearing effectors, causing CDC/ADCC (and apoptosis) to deplete those cells.
Rabbit polyclonal anti-T-cell globulin used for in vivo T-cell depletion and immunosuppression.
Rabbit polyclonal anti‑thymocyte globulin that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, adhesion/HLA molecules) and depletes T lymphocytes via complement‑dependent cytotoxicity, antibody‑dependent cellular cytotoxicity, and apoptosis, resulting in potent in vivo T‑cell immunosuppression.
YES
DIRECT
Thymoglobulin contains antibodies that bind HLA class I molecules on lymphocytes, triggering complement-dependent cytotoxicity and Fc-mediated ADCC, leading to lysis/apoptosis of target-expressing cells.
Rabbit polyclonal anti-T-cell globulin used for in vivo T-cell depletion and immunosuppression.
Rabbit polyclonal anti‑thymocyte globulin that binds multiple T‑cell surface antigens (e.g., CD2, CD3, CD4, CD8, adhesion/HLA molecules) and depletes T lymphocytes via complement‑dependent cytotoxicity, antibody‑dependent cellular cytotoxicity, and apoptosis, resulting in potent in vivo T‑cell immunosuppression.
YES
DIRECT
Thymoglobulin contains antibodies that bind HLA-DR on cell surfaces and mediate complement-dependent cytotoxicity and Fc-dependent ADCC, and can induce apoptosis upon crosslinking, leading to depletion of HLA-DR–positive cells.